Pleo Art U

Pleo Art U Arthrokehlan U (Pleo™ Art "U")

- stimulates endogenic defense capacity and acts as
adjuvant in anti-carcinomatous therapy.

Medicinal ingredient: Corynebacterium sp. DSM 4223
Pleo Art U Arthrokehlan® “U ” 6X
Drops
Liquid dilution
for oral intake, rubbing in

Active ingredient: Corynebacterium sp. extract 6X

Composition: 1 ml liquid dilution contains: Medically active substance: 1 ml Corynebacterium
sp. 6X dil. Other constituents: purified water.

Characteristics: Pleo Art U Arthrokehlan “U” is gained through the cultivation of Siphonospora polymorpha,
which have been isolated from dental granuloma, teeth with diseased
pulp and tonsils. In accordance with Dr. v. Brehmer’s method, a formol
toxoid (a detoxified culture filtrate) is produced from these cultures.
After intramuscular injection, it effects a sustained rise in the defensive
capacity.
According to experience, Stimulation of endogenic defense capacities, adjuvant in anti-carcinomato
be administered in tous therapy.
cases of:

Application: Unless otherwise prescribed: For oral intake: 1 x daily 5-10 drops before a
meal. For rubbing in: 1 x daily 5-10 drops at the location of the disease or
into the bend of the elbow.

Contraindications: In cases of known hypersensitivity to Corynebacterium sp., as a precaution,
this preparation should not be administered.

Adverse reactions: None known. Because of specific organic components of Pleo Art U Arthrokehlan “U”,
hypersensitivity theoretically may occur. In this case, discontinue medication
and treat symptomatically.

Interactions with other remedies: None known.

Side effects: None known.

Precautions: As with all medications and due to the variations of clinical studies, professional
medical advice should be sought prior to recommending this product
to women during pregnancy or breastfeeding, as well as with children.

Duration of treatment: Dependent on the advice of the physician or health care professional.

Advice: Pleo Art U Arthrokehlan “U” was previously marketed under the names Spezial-
Anatoxin “U”, Arthrisinal “U” and Toxinal.

How supplied: The following dosage forms are available: 10 ml dropper bottle 6X, 1 ml
ampule 10 and 50 6X.

Pleo Art U Arthrokehlan® “U ” 6X
Ampules
Liquid dilution for injection

Active ingredient: Corynebacterium sp. extract 6X
Composition: 1 ampule of 1 ml contains: Medically active substance: 1 ml Corynebacterium
sp. 6X aqueous dilut. Other constituents: isotonic sodium chloride
solution.

Characteristics: Arthrokehlan “U” is gained through the cultivation of Siphonospora polymorpha,
which have been isolated from dental granuloma, teeth with diseased
pulp and tonsils. In accordance with Dr. v. Brehmer’s method, a formol
toxoid (a detoxified culture filtrate) is produced from these cultures.
After intramuscular injection, it effects a sustained rise in the defensive
capacity.
According to experience, Stimulation of endogenic defense capacities, adjuvant in anti-carcinomato
be administered in tous therapy.
cases of:

Application: Unless otherwise prescribed: 0.2-1.0 ml to be injected deep intramuscularly
- regular intragluteally - at the lying patient, 2-3 x weekly. Normally the
treatment is started with the administration of drops. In case of absent or
weak reactions the dosage may be gradually raised. In case of strong reactions,
injections have to be discontinued; the treatment can be continued
with the dosage form drops. As a general advice the dosage has to be
chosen adequately, so that strong general reactions do not occur and that
the local reactions are confined to the site of injections.

Contraindications: Fever, conditions of weakness. In cases of known hypersensitivity to Corynebacterium
sp., as a precaution, this preparation should not be administered.

Adverse reactions: None known. Generally well tolerated. Occasionally local reactions like rubefaction,
swelling or painfulness may be observed, normally vanishing without
treatment. These effects are not to be seen as adverse reactions, but
rather as an expression of effectiveness. In the first 2 or 3 days after the
injection sometimes conditions of weakness, fortified expectoration, slight
painfulness of the region or subfebrile temperatures may show. Strong
general reactions are always a sign of overdosage or of incorrect injection
technique.

Interactions None known. An interval of four weeks should be kept to the administration
with other remedies: of vaccinations. In cases of simultaneous treatment with immunosuppressive remedies, the effectiveness of Pleo Art U Arthrokehlan “U” may be influenced.



Side effects: None known.

Precautions: As with all medications and due to the variations of clinical studies, professional
medical advice should be sought prior to recommending this product
to women during pregnancy or breastfeeding, as well as with children.

Duration of treatment: Dependent on the advice of the physician or health care professional.

Advice: Pleo Art U Arthrokehlan “U” was previously marketed under the names Spezial-
Anatoxin “U”, Arthrisinal “U” and Toxinal.

How supplied: The following dosage forms are available: 10 ml dropper bottle 6X, 1 ml
ampule 10 and 50 6X.